Gene and Drug Landing Page Aggregator
Gene and Drug Landing Page Aggregator (GDLPA) has links to 53 gene, 18 variant and 19 drug repositories that provide direct links to gene and drug landing pages. You can search by gene or drug name and then choose the sites that contain knowledge about your gene or drug of interest. Resources supported by the NIH Common Fund are listed first and have the CFDE logo at their top right corner.
Gene-drug interactions (GDIs) from literature :
Gene-gene interactions (GGIs) from literature :
Gene-gene interactions (GGIs) from mRNA co-expression :
ARCHS4 provides access to gene counts from HiSeq 2000, HiSeq 2500 and NextSeq 500 platforms for human and mouse experiments from GEO and SRA.
The GWAS Catalog provides a consistent, searchable, visualisable and freely available database of SNP-trait associations, which can be easily integrated with other resources.
Enrichr is an enrichment analysis tool that provides various types of visualization summaries of collective functions of gene sets.
GeneMANIA builds subnetworks around an input gene using functional association data.
The Harmonizome is a collection of knowledge about genes and proteins from 114 datasets created by processing 66 online resources to facilitate discovery via data integration.
The CFDE Search Portal is a hub for searching the CFDE data across all programs. The main page of the portal (shown below) is meant for high-level decision-making, whereas the repository (or “data browser”) allows users such as clinical researchers, bioinformatics power users, and NIH program officers to search for CFDE data.
Reactome is a free, open-source, curated and peer-reviewed pathway database that provides intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge.
PDBe Knowledge Base is a community-driven resource managed by the PDBe team, collating functional annotations and predictions for structure data in the PDB archive.
COSMIC, the Catalogue Of Somatic Mutations In Cancer, is the world's largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer.
IDG Reactome Portal provides biologist-friendly way to visualize proteins, complexes, and reactions in high-quality Reactome pathways.
AlphaFold DB provides open access to protein structure predictions for the human proteome and 20 other key organisms to accelerate scientific research.
SigCom LINCS data portal serves LINCS datasets and signatures. It provides a signature similarity search to query for mimicker or reverser signatures.
CFDE Gene Partnership uses FAIR APIs from different DCCs to find and present gene-centric knowledge.
The Pharos interface provides facile access to most data types collected by the Knowledge Management Center for the IDG program.
STRING is a database of known and predicted protein-protein interactions and a functional enrichment tool covering more than 5000 genomes.
GlyGen provides computational and informatics resources and tools for glycosciences research using information from many data sources.
MARRVEL enables users to search multiple public variant databases simultaneously and provides a unified interface to facilitate the search process.
The objective of MetGENE is to identify the reactions catalyzed by the given gene(s) RPE and the related metabolites.
Automated Vector Quantization of Massive Co-expression RNA-seq Data Improves Gene Function Prediction (PrismEXP) is a new statistical approach for accurate gene function prediction.
BioGPS is a free extensible and customizable gene annotation portal, a complete resource for learning about gene and protein function.
MGI is the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease.
The RGCSRS Appyter provides visualizations of the RNA-seq signatures induced by CRISPR knockouts and chemical perturbagens. Signatures are computed from transformed data profiles from the LINCS L1000 data.
Gene Centric GEO Reverse Search Appyter enables users to query for a gene in a species of interest; it returns an interactive volcano plot of signatures in which the gene is up- or down-regulated.
The Monarch Initiative is an integrative data and analytic platform connecting phenotypes to genotypes across species, bridging basic and applied research with semantics-based analysis.
The HGNC database is a curated online repository of approved gene nomenclature, gene groups and associated resources including links to genomic, proteomic and phenotypic information.
The Knockout Mouse Programme - International Mouse Phenotyping Consortium (KOMP-IMPC) has information about the functions of protein-coding genes in the mouse genome.
KEGG is a database resource for understanding high-level functions and utilities of the biological system from molecular-level information.
The Metabolomics Workbench serves as a repository for metabolomics data and metadata and provides analysis tools.
The mission of UniProt is to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information.
WikiPathways was established to facilitate the contribution and maintenance of pathway information by the biology community.
The Gene Ontology (GO) knowledgebase is the world’s largest source of information on the functions of genes.
PubMed comprises more than 33 million citations for biomedical literature from MEDLINE, life science journals, and online books.
The ENCODE Consortium not only produces high-quality data, but also analyzes the data in an integrative fashion.
PDB has information about the 3D shapes of proteins, nucleic acids, and complex assemblies that contribute to understanding everything from protein synthesis to health and disease.
Wikipedia is a free content, multilingual online encyclopedia written and maintained by a community of volunteers through a model of open collaboration, using a wiki-based editing system